%0 Journal Article
%T Bone marrow transplantation: graft versus host disease and oral changes = Transplante de medula 車ssea: doen a enxerto versus hospedeiro e altera  es orais
%A Lima
%A Emeline das Neves de Ara迆jo et al.
%J Revista Odonto Ci那ncia
%D 2012
%I Editora da Pontif赤cia Universidade Cat車lica do Rio Grande do Sul (EDIPUCRS)
%X Objetivo: Este estudo objetivou avaliar a preval那ncia de altera  es orais e sua associa  o com a doen a enxerto versus hospedeiro (DEVH) em pacientes submetidos a transplante de medula 車ssea (TMO). Metodologia: A amostra consistiu de 51 pacientes. Por meio de question芍rio, foram coletados dados sobre idade, sexo, doen a, tipo e tempo de transplante, origem das c谷lulas e ocorr那ncia da DEVH. Foram realizados exames cl赤nicos extra e intraoral por profissionais especializados. Resultados: DEVH sist那mica foi observada em 32,5% dos pacientes transplantados alog那nicos, todos apresentando manifesta  es orais. Tamb谷m houve uma associa  o estatisticamente significante entre DEVH sist那mica e manifesta  es orais (P<0,001). Conclus o: Diante da preval那ncia de altera  es orais relativamente alta associada 角 DEVH em pacientes submetidos ao TMO, o presente estudo confirma a necessidade de se considerar a odontologia no exame, diagn車stico, tratamento e progn車stico de poss赤veis complica  es ap車s o transplante de medula 車ssea. Purpose: This study aimed to evaluate the prevalence of oral changes and their association with graft versus host disease (GVHD) in patients undergoing bone marrow transplantation (BMT). Methods: The sample consisted of 51 BMT patients. A questionnaire was used to collect data on age, gender, disease, type and time of transplant, cell origin, and GVHD occurrence. The extraoral and intraoral clinical examinations were performed by specialized professionals. Results: Systemic GVHD was observed in 32. 5% of the allogeneic transplant patients, and all of the patients with GVHD had oral manifestations. There was a statistically significant association between systemic GVHD and oral manifestations (P<0. 001). Conclusion: Given the relatively high prevalence of oral changes associated with GVHD in patients undergoing BMT, this study confirms the need to consider dental aspects in the examination, diagnosis, treatment and prognosis of possible complications after BMT.
%K ODONTOLOGIA
%K PATOLOGIA BUCAL
%K TRANSPLANTE DE MEDULA 車SSEA
%U http://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/9846/7679