%0 Journal Article
%T PREPARATION, CHARACTERIZATION AND EVALUATION OF CELLULOSE- ETHYL CELLULOSE CO-PROCESSED EXCIPIENT IN THE FORMULATION DEVELOPMENT OF TABLETS
%A K. P. R. Chowdary
%A D. Udaya Chandra
%A N. Sadana
%A P. Madhavi
%J International Journal of Chemical Sciences and Research
%D 2012
%I 
%X An efficient platform for the manipulation of excipient functionality is provided by co-processing two or more existing excipients. Co-processing is based on the novel concept of two or more excipients interacting at the sub particle level, the objective of which is to provide a synergy of functionality improvements as well as masking the undesirable properties of individual excipients The objective of the present study is to prepare and characterize cellulose-ethyl cellulose (Cellulose-EC) co-processed excipient and to evaluate its application as directly compressible vehicle in tablet formulations. Cellulose ¨CEC coprocessed excipient was prepared by kneading method and was characterized by determining melting point, solubility, swelling index in water, pH, and micromeritic characters namely particle size, bulk density, tapped density, angle of repose and compressibility index and evaluated for its application as directly compressible vehicle in tablet formulations. Cellulose-EC co-processed excipient prepared by kneading method is granular,discrete and free flowing. It is insoluble in water and aqueous fluids of pH 1.2, 4.5 and 7.4. It exhibited slight swelling (24%) in water. Cellulose-EC co-processed excipient has excellent flow properties alone and as blends with selected drugs it exhibited excellent to good flow properties. Tablets of (i) pioglitazone and (ii) gliclazide prepared by direct compression method employing Cellulose-EC co-processed excipient as DCV were of good quality with regard to drug content, hardness, friability and disintegration time. The tablets formulated disintegrated rapidly within 1-5 min. With both the drugs, the tablets prepared gave rapid dissolution of the contained drug and fulfilled the official (IP) dissolution rate test specification prescribed in each case. Thus Cellulose-EC co-processed excipient developed in this study was found to be a promising directly compressible vehicle for the preparation of compressed tablets.
%K Cellulose ¨C Ethyl celluloseCo- processed Excipient
%K Directly compressible vehicle
%K Co-processed Excipient
%K Pioglitazone
%K Gliclazide
%K Tablets
%U http://www.ijcsr.co.in/Documents/Volumes/Vol%202%20issue%205/3%20-%20IJCSR%20v02i05%20so%20Chowdhry.pdf