%0 Journal Article
%T Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists
%A Thelma P Polyviou
%A Yannis P Pitsiladis
%A Wu Chean Lee
%A Takas Pantazis
%A Catherine Hambly
%A John R Speakman
%A Dalia Malkova
%J Journal of the International Society of Sports Nutrition
%D 2012
%I BioMed Central
%R 10.1186/1550-2783-9-29
%X To determine whether Cr/Gly-induced thermoregulatory and cardiovascular responses are maintained when the majority (~75%) of the Glu in the Cr/Gly supplement is replaced with the insulintropic agent alpha lipoic acid (Ala).22 healthy endurance trained cyclists were randomly assigned to receive either 20£¿g/day (4£¿¡Á£¿5£¿g/day) of Cr, 2£¿g .kg-1 BM per day (4£¿¡Á£¿0.5£¿g .kg-1 BM per day) of Gly and 150£¿g/day (4£¿¡Á£¿37.5£¿g/day) of Glu or 20£¿g/day (4£¿¡Á£¿5£¿g/day) of Cr monohydrate, 2£¿g .kg-1 BM per day (4£¿¡Á£¿0.5£¿g .kg-1 BM per day) of Gly (100£¿g/day (4£¿¡Á£¿25£¿g/day) of Glu and 1000£¿mg/day (4£¿¡Á£¿250£¿mg/day) of Ala for 7£¿days for 7£¿days. Exercise trials were conducted pre- and post-supplementation and involved 40£¿min of constant-load cycling exercise at 70% O2 max by a self-paced 16.1£¿km time trial at 30¡ãC and 70% relative humidity.Median and range values of TBW increased significantly by 2.1 (1.3-3.3) L and 1.8 (0.2-4.6) L in Cr/Gly/Glu and Cr/Gly/Glu/Ala groups respectively (P£¿=£¿0.03) and of BM not significantly by 1.8 (0.2-3.0) kg and 1.2 (0.5-2.1) kg in Cr/Gly/Glu and in Cr/Gly/Glu/Ala, respectively (P£¿=£¿0.75). During constant load exercise, heart rate (HR) and core temperature (Tcore) were significantly lower post-supplementation: HR was reduced on average by 3.3£¿¡À£¿2.1 beats/min and by 4.8£¿¡À£¿3.3 beats/min (mean ¡À SD) and Tcore by 0.2£¿¡À£¿0.1 (mean ¡À SD) in the Cr/Gly/Glu and Cr/Gly/Glu/Ala, respectively The reduction in HR and Tcore was not significantly different between the supplementation groups.In comparison to the established hyper hydrating Cr/Gly/Glu supplement, supplement containing Cr/Gly/Ala and decreased amount of Glu provides equal improvements in thermoregulatory and cardiovascular responses during exercise in the heat.
%K Creatine
%K Glycerol
%K Alpha Lipoic Acid
%K Thermoregulation
%K Cardiovascular Response
%K Water Loading
%K Exercise
%U http://www.jissn.com/content/9/1/29/abstract