%0 Journal Article
%T Diastereoselective Spiroannulation of Phenolic Derivatives: Effect of Steric Hindrance on the Diastereoselectivity
%A Guy L Plourde
%A Lyndia M. Susag
%J International Journal of Chemistry
%D 2011
%I 
%R 10.5539/ijc.v3n1p3
%X This study was aimed at determining the effect, if any, that steric factors may have on the diastereoselectivity in the spiroannulation of simple phenols.  A series of phenols bearing different size substituents ortho to the phenolic hydroxyl were synthesized and spiroannulated to the corresponding spiroethers in good to excellent yields (76-94%).  However, the diastereoselectivity of the reaction remain mostly unchanged suggesting that stereoelectronic rather then steric factors influence the diastereoselectivity in this reaction.
%U http://www.ccsenet.org/journal/index.php/ijc/article/view/6818