%0 Journal Article
%T HEPATIC MALIGNANCY - A CHALLENGE FOR EARLY DIAGNOSIS
%A Dr.Anil Batta
%A Associate Professor
%J International Journal of Chemical Sciences and Research
%D 2011
%I 
%X Liver cancer is the third most common cause of death from cancer. This is despite the fact that damaged liver has an amazing ability to regenerate itself and the body needs only about 10% of the liver to live. Liver cancer starts within a single cell and it starts dividing in a disorganized and uncontrolled manner. They fail to perform the normal functions. Eventually a lump or tumor is formed which may be benign or malignant. Malignant mass is inclined to spread and is called metastasis. Liver is very common place for it, since it offers a soft, spongy blood-rich tissue. The diagnosis of hepatic malignancy in early stages is extremely judicious as it can expedite treatment in the budding stage. It is a multimodal approach of a surgeon, a radiotherapist, an interventional radiologist and a biochemist. Various biochemical parameters have decisive role in making diagnosis in the early stages. Obstructionof bile duct increases 5ĄŻNT values even in preclinical phase. But dependence on a single enzyme may lead to erroneous diagnosis so its sensitivity and specificity was compared with alkaline phosphatase, AST, ALT and serum bilirubin in a variety of malignancies. The results were extremely satisfactory.5ĄŻNT has an edge over the other biochemical parameters when comparison was made. But single handed approach was not enough. So when it was juxtaposed with ALP, aminotransferases and bilirubin levels, it provides immaculate results in making diagnosis at an early stage.
%K Hepatocellular carcinoma
%K Biopsy
%K metastasis
%K MRI
%K clotting time
%K transplantation.
%U http://www.ijcsr.co.in/Documents/Volumes/Vol%20I%20issue%204/ijcsr%2020110104(3).pdf