%0 Journal Article
%T The Synthesis of Pyrazole Derivatives Based on Glucose
%A Kui Du
%A Yi-Jia Mei
%A Xian-Ting Cao
%A Peng-Fei Zhang
%J International Journal of Chemical Engineering and Applications
%D 2013
%I IACSIT Press
%R 10.7763/ijcea.2013.v4.303
%X Heterocyclic compounds and glucose derivatives play important role in organic chemistry and biological chemistry for their richc functionality. A facile and convient protocol had been developed for the synthesis of a series of novel glucosyl pyrazole derivatives starting from D-glucose. The protected glucose by O-pivaloyl groups reacted with BTC and obtained corresponding 2-isocyanate glucose, which effectively avoid the harsh conditions and highly toxic agents compared to the traditional method. Glucosyl pyrazole derivatives were then prepared through the reaction of pyrazole and its derivatives with 2-isocyanate glucose with good yields.
%K Heterocycle
%K glucose
%K pyrazole
%K synthesis.
%U http://www.ijcea.org/papers/303-A003.pdf