%0 Journal Article
%T Disease caused by non-tuberculous mycobacteria: diagnostic procedures and treatment evaluation in the North of Buenos Aires Province
%A Bel谷n Imperiale
%A Mart赤n Zum芍rraga
%A Andrea Gioffr谷
%A Beatriz Di Giulio
%J Revista argentina de microbiologˋ-a
%D 2012
%I Asociaci車n Argentina de Microbiolog赤a
%X Non-tuberculous mycobacteria (NTM) have emerged as pathogens frequently associated to HIV co-infection. The aims of this study were to describe the clinical importance of NTM in patients from the North of Buenos Aires Province and the drug-susceptibility patterns in relation with the therapy used. A total of 23,624 clinical specimens were investigated during the period 2004-2010. Ziehl-Neelsen stain and cultures were used for diagnosis. Molecular and biochemical tests were performed to identify the mycobacteria. TB and mycobacterioses cases were 2 118 and 108 respectively. Sixteen NTM species were found: Mycobacterium avium and Mycobacterium intracellulare as the main causative agents. Infections produced by more than one species at the same time were confirmed (4 cases). Macrolides and fluoroquinolones were the most active in vitro drugs. Treatment evaluation showed that 68.0 % of the cases completed the therapy, 20 % died; and 12 % were relapses. The cases in which the treatment outcome was evaluated received an individual tailor-made therapeutic scheme including those drugs showing in vitro activity and presumed in vivo usefulness. More than a quarter of the patients had HIV co-infection and the majority of the deaths were associated with this co-infection. Enfermedad causada por micobacterias no tuberculosas: diagn車stico y evaluaci車n del tratamiento en el norte del Gran Buenos Aires. Las micobacterias no tuberculosas (MNT) emergieron como pat車genos frecuentemente asociados a la co-infecci車n con el HIV. EL objetivo del estudio fue describir la importancia cl赤nica de las MNT en pacientes de la regi車n norte de la provincia de Buenos Aires y los patrones de drogo-sensibilidad en relaci車n con la terapia empleada. Se investig車 un total de 23.624 espec赤menes cl赤nicos durante, el per赤odo 2004-2010. La tinci車n de Ziehl-Neelsen y los cultivos se utilizaron para diagn車stico. Las micobacterias fueron identificadas mediante pruebas bioqu赤micas y moleculares. Los casos de tuberculosis y micobacteriosis fueron 2 118 y 108, respectivamente. Se encontraron 16 especies de MNT, siendo las principales, Mycobacterium avium y Mycobacterium intracellulare. En 4 casos se confirmaron infecciones producidas por m芍s de una especie al mismo tiempo. Los macr車lidos y las fluoroquinolonas tuvieron mayor actividad in vitro. La evaluaci車n del tratamiento confirm車 que el 68 % de los casos complet車 la terapia; 20 % muri車 y el 12 % recay車. Los casos en los que se evalu車 el tratamiento recibieron un esquema terap谷utico individual incluyendo aquellas drogas que mostraron actividad in vi
%K Micobacterias no tuberculosas
%K Diagn車stico Tratamiento
%K Non-tuberculous mycobacteria
%K Diagnosis and treatment
%U http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-75412012000100002