%0 Journal Article
%T Serotype distribution of pneumococci isolated from pediatric patients with acute otitis media and invasive infections, and potential coverage of pneumococcal conjugated vaccines Distribuci車n de serotipos de neumococos aislados de pacientes pedi芍tricos con otitis media aguda e infecciones invasivas y su cobertura potencial a trav谷s de vacunas conjugadas
%A Vanesa Reijtman
%A Sof赤a Fossati
%A Claudia Hern芍ndez
%A Patricia Sommerfleck
%J Revista argentina de microbiologˋ-a
%D 2013
%I Asociaci車n Argentina de Microbiolog赤a
%X A 16-month prospective, descriptive study was conducted on pneumococcal serotype distribution isolated from children with acute otitis media (A邦M) and invasive infections (INV). Eighty-nine children with pneumococcal INV and 324 with a first episode of AOM were included. Bacterial pathogens (N = 326) were isolated from the middle-ear fluid of 250 patients. A total of 30 pneumococcal serotypes were identified. Prevalent serotypes were 14, 19A, 9V, 3, 19F, 6A, 23F, and 18C in AOM and 14, 1, 19A, 5, 12F, 6B, and 18C in INV. Potential coverage with PCV10 vaccine would be 46.5 % and 60.7 % for pneumococci involved in AOM and INV, respectively; it would be 71.7 % and 73 % with PCV13. PCV10, conjugated with a Haemophilus protein, would have an immunologic coverage of 39.9 % for AOM vs. 18.5 % with PCV13. However, differences in the prevention of INV were crucial for the decision to include the 13-valent vaccine in the national calendar for children less than two years old in Argentina. Se realiz車 un estudio prospectivo descriptivo sobre la distribuci車n de serotipos de neumococos aislados de ni os con otitis media aguda (OMA) y con infecciones invasivas (INV) en un per赤odo de 16 meses. Se incluyeron 89 ni os con INV neumoc車cicas y 324 con un primer episodio de OMA. Trescientos cuarenta y seis pat車genos se aislaron de las secreciones de o赤do medio obtenidas de 250 pacientes. Se identificaron 30 serotipos y los m芍s prevalentes fueron el 14, 19A, 9V, 3, 19F, 6A, 23F y 18C en OMA y el 14, 1, 19A, 5, 12F, 6B y 18C en INV. La cobertura potencial con la vacuna PCV10 ser赤a de 46,5 % y 60,7 % para neumococos involucrados en OMA y en INV, respectivamente; con la PCV13, esta ser赤a de 71,7 % y 73 %. La PCV10 conjugada con una prote赤na de Haemophilus tendr赤a una cobertura inmunol車gica del 39,9 % para OMA, contra una cobertura del 18,5 % de la PCV13. Sin embargo, las diferencias en la prevenci車n de INV fueron determinantes a la hora de considerar incorporarla al calendario nacional de vacunaci車n para ni os menores de 2 a os en la Argentina.
%K Streptococcus pneumoniae
%K Serotipos
%K Pediatr赤a
%K Otitis media aguda
%K Infecciones invasivas
%K Vacunas
%K Streptococcus pneumoniae
%K Serotype
%K Pediatrics
%K Acute otitis media
%K Invasive infections
%K Vaccines
%U http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-75412013000100005