%0 Journal Article
%T Enfermedad injerto vs hospedero postransfusional en un paciente con leucemia linfobl芍stica aguda Graft vs host disease after transfusion in a patient with acute linfoblastic leukemia
%A TR Nijamin
%A LJ Jaime
%A JA Laffargue
%A G Cao
%J Revista Argentina de Dermatolog赤a
%D 2012
%I Asociaci車n Argentina de Dermatolog赤a
%X La enfermedad injerto vs hospedero (EICH) es un proceso inmunol車gico, desencadenado por linfocitos T de un donante inmunocompetente, que reaccionan contra los tejidos de un receptor inmunocomprometido. Esto origina da o multiorg芍nico severo en el agente receptor. Las manifestaciones cut芍neas son un signo cl赤nico relevante en per赤odos tempranos. La EICH postranfusional (EICH-PT) es una entidad poco frecuente y con alta tasa de mortalidad, que se observa en pacientes luego de transfusiones con hemoderivados no irradiados. Los corticoides son el pilar fundamental del tratamiento, una vez instalado el cuadro. La prevenci車n con leucorreducci車n e irradiaci車n de los componentes sangu赤neos, constituye el sustento primordial para evitar su desarrollo. Presentamos un paciente de 5 a os de edad, con un diagn車stico de leucemia linfobl芍stica aguda de alto riesgo, de m迆ltiples transfusiones de gl車bulos rojos sin tratamiento radiante previo, a quien se le realiza el diagn車stico dermatol車gico e histopatol車gico de EICH aguda postransfusional. Graft vs host disease (GVHD) is a process triggered by immune T cells, that react immunocompetent donor tissue against a recipient immunocompromised. This causes severe multiorgan damage in the receiving agent. Cutaneous manifestations are an important clinical sign in early periods. Postranfusional GVHD (GVHD-PT) is a rare entity with high mortality rate, observed in patients after transfusion with blood products not previously irradiated. Corticosteroids are the mainstay of treatment after installation of the box, however prevention with leukoreduction and irradiation of blood components remains the mainstay to prevent its development. We present a patient 5 years of age, diagnosed with acute lymphoblastic leukemia at high risk with a history of multiple transfusions of red blood cells without prior radiation treatment, who is performed dermatological and histopathological diagnosis posttransfusion acute GVHD.
%K Enfermedad injerto contra hospedero postransfusional
%K EICH
%K Transfusi車n de gl車bulos rojos
%K Postransfusion graft versus host disease
%K GVHD
%K Red blood cells transfusion
%U http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-300X2012000400003