%0 Journal Article
%T Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay
%A Farzin Hadizadeh
%A Alireza Moradi
%A Goli Naghibi
%A Mojgan Vojdani
%J International Journal of Biomedical Science
%D 2007
%I 
%X In view of potential biological activities of some succinic acid derivatives, we synthesized some novel N-[4-(4-morpholinosulfonyl)-phenyl]-succinamides (6a, c; 7a, c) and N-[4-(benzylaminosulfonyl) phenyl]-succinamides (6b, d; 7b, d) derivatives as antitumor agents. The antitumor activity of compounds was studied using the potato disk bioassay technique (Figure 1). Vincristine at 0.25mg/ml was employed as positive control and caused -67.24% inhibitions. Compound 7b at 1 mg/ml caused -80.50% tumor inhibitions with highest activity among compounds tested.
%K succinamides
%K antitumor
%K potato disc
%U http://ijbs.org/User/ContentFullTextFrame.aspx?VolumeNo=3&StartPage=60