%0 Journal Article
%T Lipid Transport through the Fetoplacental Barrier by the Fatty Acid-Binding Proteins in Pregnant Women with Herpes Virus Infection in the third Trimester
%A Michael T. Lucenko
%A PhD
%A ScD
%A Irina A. Andrievskaya
%A PhD
%A ScD
%A Natalia A. Ishutina
%A PhD
%J International Journal of BioMedicine
%D 2012
%I International Medical Research and Development Corporation
%X In this study, the transport of the long chain polyunsaturated fatty acids (LCPUFAs) from the lacunar blood through the syncytiotrophoblast of the placental villi to the fetal cord blood via a saturable protein-mediated mechanism by the heart-type fatty acid-binding proteins (H-FABPs) has been examined. Exacerbation of the herpes simplex viruses (HSV-1) in the third trimester of gestation reduces the delivery of the fatty acid-binding proteins to the syncytiotrophoblast. During exacerbation of the HSV-1 infection, the selective transfer of the LCPUFAs across the syncytiotrophoblast basal plasma membrane into the fetal cord blood was observed. The supply of anti-inflammatory ¦Ø-3 PUFAs was reduced; however, the inflow of inflammatory arachidonic acid and other ¦Ø-6 PUFAs into the fetal blood was increased.
%K fetoplacental unit
%K long chain polyunsaturated fatty acids
%K heart-type fatty acid-binding proteins
%K herpes virus infection.
%U http://www.ijbm.org/articles/2_4_BR2.pdf