%0 Journal Article
%T Interleukin-1B and Interleukin-1 Receptor Antagonist in Patients with Helicobacter pylori Associated Diseases
%A Olga V. Shtygasheva
%A PhD
%A ScD
%A Elizaveta S. Ageeva
%A PhD
%J International Journal of BioMedicine
%D 2012
%I International Medical Research and Development Corporation
%X The ethnic people of the Republic of Khakassia (the Khakas) with ulcer disease show a significant T-cell activation and humoral immune response when compared with the Europoids. The reasons for such differences could be due to certain ethno-specific allelic variants of the interleukins, which considerably change the degree of cytokine expression. The aim was to study the peculiarities of the association of the interleukin-1 (IL-1) gene polymorphisms and interleukin-1 receptor antagonist (IL-1Ra). Patients with chronic gastritis and ulcer disease were examined using the restriction analysis method. The most wide-spread allelic variants among the Khakas were discovered to be §³§³ IL-1¦Â and R4R4 IL-1Ra. In this study, we suggest the necessity to define the population¡¯s risk and the protective genotypes that promote Helicobacter pylori-associated ulcer disease among the Khakas people.
%K Helicobacter pylori
%K ulcer disease
%K the Khakas
%K Th1/Th2 immune response
%K gene polymorphism
%K interleukin-1.
%U http://www.ijbm.org/articles/2_2_CR6.pdf