%0 Journal Article
%T In Silico Analysis for Transcription Factors With  Binuclear Cluster DNA-Binding Domains in Candida albicans
%A Sergi Maicas
%A Inmaculada Moreno
%A Almudena Nieto
%A Micaela G¨®mez
%A Rafael Sentandreu
%A Eulogio Valent¨ªn
%J Comparative and Functional Genomics
%D 2005
%I Hindawi Publishing Corporation
%R 10.1002/cfg.492
%X A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)2C6-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX2CysX6CysX5-16CysX2CysX6-8Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)2C6 transcription factors have been found in the genome of C. albicans.
%U http://www.hindawi.com/journals/cfg/2005/194685/abs/