%0 Journal Article
%T EVALUATION OF SOLUBILITY OF SIMVASTATIN USING ¦Â-CYCLODEXTRIN BY SOLID DISPERSION TECHNIQUE
%A Punitha S.
%A Senthil Kumar KL
%J International Journal of Biomedical Research
%D 2011
%I 
%R 10.7439/ijbr.v1i2.58
%X Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin-¦Â cyclodextrin dispersions were prepared with a view to study the influence of ¦Â-CD on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of ¦Â-CD as carrier by Physical mixture, solvent evaporation method, Kneading method and Fusion Method. They were evaluated for drug content, moisture content, FTIR spectral studies, solubility, in-vitro dissolution and release kinetics. The solubility profile indicated that there is increase in solubility of Simvastatin when ¦Â-CD concentration is increased. The solid dispersion complex of drug (1:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions (1:1 and 1:3). This in turn can improve the bioavailability. FT-IR shows the complexation and compatibility of rug and carrier.
%K Simvastatin
%K ¦Â cyclodextrin
%K complexation
%U http://www.ssjournals.com/index.php/ijbr/article/view/58