%0 Journal Article
%T Regulatory effect of heat shock protein 70 in stress-induced rat intestinal epithelial barrier dysfunction
%A Ping-Chang Yang
%A Ya-Hong Tu
%A Mary H. Perdue
%A Christine Oluwole
%J North American Journal of Medical Sciences
%D 2009
%I North American Journal of Medical Sciences
%X Background: Psychological stress is one of the factors associated with many human diseases; the mechanisms need to be further understood. Methods: Rats were subjected to chronic water avoid stress. Intestinal epithelial heat shock protein (HSP) 70 was evaluated. The intestinal epithelial permeability was examined with Ussing chamber technique. Results: HSP70 was detected in normal intestinal epithelial cells. Psychological stress decreased HSP70 in the intestinal epithelial cells that correlated with the stress-induced intestinal epithelial hyperpermeability. Pretreatment with HSP70 abrogated stress-induced intestinal barrier dysfunction. Conclusions: Chronic stress inhibits HSP70 activity in rat intestinal epithelial layer that is associated with intestinal epithelial barrier dysfunction, which can be prevented by pretreatment with HSP70 protein.
%K Intestine
%K Epithelium
%K Heat shock protein 70
%K Stress.
%U http://najms.org/resources/PDF+9-15+Regulatory+effect+of+heat+shock+protein+70+in+stress-induced+rat+intestinal+epithelial+barrier+dysfunction.pdf