%0 Journal Article
%T Expression of integrin alphavbeta6 in the intestinal epithelial cells of patients with inflammatory bowel disease
%A Bai-Sui Feng
%A Xiao Chen
%A Ping Li
%A Peng-Yuan Zheng
%J North American Journal of Medical Sciences
%D 2009
%I North American Journal of Medical Sciences
%X Background and aims: The prevalence of inflammatory bowel disease (IBD) is about 0.05% in industrialized countries. The pathogenesis of IBD remains to be further understood. The present study aims to elucidate the expression of integrin ¦Áv¦Â6 in the intestinal mucosa of patients with IBD. Materials and Methods: Colonic biopsy was obtained from a group of IBD patients. The expression of ¦Áv¦Â6 in the intestinal mucosa was detected by Western blotting. Human colonic epithelial cell line T84 cells were stimulated by microbial antigen flagellin. The expression of ¦Áv¦Â6 in T84 cells was evaluated by quantitative RT-PCR and Western blotting. Results: The levels of ¦Áv¦Â6 in the intestinal mucosa were much lower than it in normal control subjects. The serum levels of myeloperoxidase (MPO) were higher in IBD patients that were negatively correlated with the levels of ¦Áv¦Â6 in the intestinal mucosa. The expression of ¦Áv¦Â6 was detectable in T84 cells at na ve status that could be upregulated by exposure to microbial antigen flagellin. Pretreatment with MPO dramatically suppressed the expression of ¦Áv¦Â6 in T84 cells. Conclusions: We conclude that the expression of ¦Áv¦Â6 was suppressed in IBD intestinal mucosa, which could be resulted from the high levels of MPO.
%K Inflammatory bowel disease
%K intestine
%K mucosa
%K integrin
%K oral tolerance.
%U http://www.najms.org/resources/PDF+200-204+Expression+of+integrin+alphavbeta6+in+the+intestinal+epithelial+cells+of+patients+with+inflammatory+bowel+disease.pdf