%0 Journal Article
%T Sensitive Assay for Carvedilol in Tablets and Spiked Human Plasma Using a Flow-Injection Chemiluminometric Method
%A Nawal Al Arfaj
%A Heba H. Abdine
%A Maha A. Sultan
%J International Journal of Biomedical Science
%D 2007
%I 
%X A simple and sensitive chemiluminometric method using flow injection (FI) is developed for the determination of carvedilol, based on the reaction of carvedilol with tris (2, 2¡¯-bipyridyl) ruthenium (II), and KMnO4 in sulfuric acid medium. Under the optimum conditions; the chemiluminescence (CL) intensity is a linear function of carvedilol concentration over the range of 0.04¨C1.0 ¦Ìg ml¡¥1 (9.8 ¡Á 10¡¥8 - 2.5 ¡Á 10¡¥6 mol L¡¥1) with a detection limit (S/N=3) of 0.025 ¦Ìgml¡¥1 (6.2 ¡Á 10¡¥8 mol L¡¥1). The relative standard deviation of the proposed method calculated from 10 replicate injections of 0.4 ¦Ìg ml¡¥1 carvedilol is 0.95%. The sample throughput is 90 samples h¡¥1. The method is applied successfully to the determination of carvedilol in tablets dosage form and spiked human plasma.
%K carvedilol
%K chemiluminescence
%K flow injection
%K Tris (2
%K 2¡¯ bipyridyl) ruthenium (II)
%K KMnO4
%K tablets
%K human plasma
%U http://ijbs.org/User/ContentFullTextFrame.aspx?VolumeNo=3&StartPage=132