%0 Journal Article
%T Effect of IGF-1 on Expression of GH Receptor, IGF-1, IGF-1 Receptor, KAP3.2 and KAP6-1 mRNA in the Skin of Sheep
%A Chengxian Zhang
%A Herong Liao
%A Yan Zhao
%J International Journal of Biology
%D 2009
%I 
%R 10.5539/ijb.v1n1p65
%X Thirty-six healthy and similar Chinese Merino sheep were selected and divided into six groups at random. The treatment group was injected intradermally with 0.5 mL IGF-1 (10ng/mL). Treatment skin tissue of sheep were sampled respectively for 0,3,6,9,12 and 50 days and the skin expression of growth hormone receptor (GHR), insulin-like growth factor1 (IGF-1), insulin-like growth factor receptor (IGF- R), KAP3.2 and KAP6-1 mRNA were measured by RT-PCR. The results indicated that IGF-1 could degrade GHR gene expression, have no effect of IGF-1 and IGF-1R gene expression, and increase significantly KAP3.2 and KAP6-1 gene expression. Taken together these findings that the improvement of KAP3.2 and KAP6-1 gene expression may correlates with other pathway beyond the insulin-like growth factor axis.
%U http://www.ccsenet.org/journal/index.php/ijb/article/view/662