%0 Journal Article
%T Liquid Chromatographic Determination of Alogliptin in Bulk and in itsPharmaceutical Preparation
%A Ramzia I. El-Bagary
%A Ehab F. Elkady
%A Bassam M. Ayoub
%J International Journal of Biomedical Science
%D 2012
%I 
%X In this work, areversed-phase liquid chromatographic (RP-LC) method has been developed for the determination of alogliptin (ALG) based on isocratic elutionusing a mobile phase consisting of potassium dihydrogen phosphate buffer pH (4.6)-acetonitrile (20:80,v/v) at a flow rate of 1 mL min 1 with UV detection at 215 nm. Chromatographic separation was achieved on a Symmetry  cyanide column (150 mm ¡Á 4.6 mm, 5 ¦Ìm). Linearity, accuracy and precision were found to be acceptable over the concentration range of 5-160 ¦Ìg mL 1 for ALG in bulk. The optimized method was validated and proved to be specific, robust and accurate for the quality control of ALG in pharmaceutical preparations.
%K alogliptin
%K reversed-phase liquid chromatography
%K isocratic elution
%K pharmaceutical preparation
%U http://www.ijbs.org/User/ContentFullTextFrame.aspx?VolumeNO=8&StartPage=215