%0 Journal Article
%T LIPID PEROXIDATION MEASURED AS SERUM MALONDIALDEHYDE AND VITAMIN-C AS OXIDATIVE-ANTIOXIDATIVE BIOMARKERS IN TYPE II DIABETIC PATIENTS
%A Suchitra M. M.
%A Pallavi M.
%A Alok Sachan
%A Seshadri V. Reddy
%J International Journal of Biomedical and Advance Research
%D 2011
%I Scholar Science Journals
%R 10.7439/ijbar.v2i9.50
%X Background: Oxidative stress (OS) has been implicated in the initiation, progression and pathology of type 2 diabetes mellitus (DM) and its associated complications. Methods: Serum samples were screened for lipid peroxidation marker, malondialdehyde (MDA), Vitamin C (Vit-C), and lipid parameters from 35 type 2 diabetic patients without complications and 30 non-diabetic healthy controls. Results: There were significant differences in all biochemical parameters in diabetic group compared to control group with a significant elevation in all the parameters but Vit-C and high density lipoproteins (HDL) found to be decreased significantly (p<0.05). Pearsona? s correlation analysis revealed that MDA was found to be negatively correlated with Vit-C (r = 0.28, p<0.05). Conclusion: Type 2 DM is associated with lipid abnormalities and OS causing increased lipid peroxidation and depleted antioxidant levels. As these changes might lead to diabetic complications, our findings suggest the supplementation of antioxidants as a therapeutic measure to type 2 DM patients.
%K Diabetes
%K Dyslipidemia
%K Oxidative stress
%K Vitamin C
%K Malondialdehyde
%U http://ijbar.ssjournals.com/index.php/journal/article/view/95