%0 Journal Article
%T A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
%A Ellen Van Damme
%A Kris Laukens
%A Thanh Hai Dang
%A Xaveer Van Ostade
%J International Journal of Biological Sciences
%D 2010
%I Ivyspring International Publisher
%X Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins. Here we present a manually curated network of the PML-NB interactome based on extensive literature review including database information. By compiling 'the PML-ome', we highlighted the presence of interactors in the Small Ubiquitin Like Modifier (SUMO) conjugation pathway. Additionally, we show an enrichment of SUMOylatable proteins in the PML-NBs through an in-house prediction algorithm. Therefore, based on the PML network, we hypothesize that PML-NBs may function as a nuclear SUMOylation hotspot.
%U http://www.biolsci.org/v06p0051.htm