%0 Journal Article
%T ROLE AND EFFECT OF CARRIER ON DRY POWDER INHELERS PERFORMANCE
%A Swati Modgil*
%A Vandna Dhiman
%A Jaspreet Ramana
%J International Journal of Bioassays
%D 2013
%I 
%X The performance of dry powder aerosols for the delivery of drugs to the lungs has been studied extensively in the last decade. The focus for different research groups has been on aspects of the powder formulation, which relate to solid state, surface and interfacial chemistry, bulk properties (static and dynamic) and measures of performance. Consequently, the adoption of formulation approaches that on a predictive basis lead to desirable performance has been an elusive goal but one that many agree is worth striving towards. Dry powder inhaler (DPI) is generally formulated as a powder mixture of coarse carrier particles and micronized drug with aerodynamic diameters of 1-5 ¦Ìm. Carrier particles are used to improve drug particle flow ability, thus improving dosing accuracy, minimizing the dose variability compared with drug alone and making them easier to handle during manufacturing operations. Lactose is the most common and frequently used carrier in DPIs formulations and nowadays various inhalation grades of lactose with different physico-chemical properties are available on the market. Therefore, the purpose of this paper is to initiate a discussion of the use of a variety of techniques to elucidate dry particle behavior that might guide the data collection process is to review evolution of lactose as a carrier in inhalable formulations, their production and the impact of its physico-chemical properties on drug dispersion. This review offers a perspective on the current reported studies to modify lactose for better performance in DPIs.
%K Aerosols
%K Surface Chemistry
%K Pulmonary Drug Delivery
%K Physico-Chemical Characterization
%K Particle Size
%U http://ebioscholar.com/ojs/index.php/ijb/article/view/274