%0 Journal Article
%T Valor pron¨®stico de la hiperuricemia en la insuficiencia card¨ªaca cr¨®nica Prognostic value of hyperuricemia in chronic heart failure
%A Alejandro Mart¨ªnez S
%A Alejandro Gonz¨¢lez M
%A Cristi¨¢n Cerda D
%A Pedro P¨¦rez C
%J Revista m¨¦dica de Chile
%D 2004
%I Sociedad M¨¦dica de Santiago
%X Background: Hyperuricemia has been proposed as a risk marker in chronic heart failure, but its value as an independent prognostic is not well established. Aim: To determine the prognostic value of hyperuricemia, in patients with chronic stable heart failure. Patients and methods: Forty six male patients with chronic heart failure, aged 62¡À13 years, were studied. Their ejection fraction was less than 40% and their serum creatinine was less than 2 mg/dl. Serum uric acid and catecholamines, maximal oxygen consumption (VO2 max) and left ventricular ejection fraction were measured. Mortality and the need for cardiac transplant were recorded as endpoints during a mean follow up of 39¡À18 months. The relationship between basal measures and the occurrence of events was analyzed using univariate and multivariate methods. Results: Basal VO2 max and left ventricular ejection fraction were 16¡À4.6 ml/kg/min and 22¡À7% respectively. Eighteen patients died and three required transplantation during the follow up. Patients reaching these endpoints had a lower VO2 max and left ventricular ejection fraction and higher uric acid levels. Multivariate analysis accepted left ventricular ejection fraction (relative risk 0.89, 95% CI 0.82-0.97) and serum uric acid (relative risk 1.335 95% CI 1.02-1.74) as significant predictors of events. The relative risk for cardiac transplantation was 7.07 times higher among those with a serum uric acid over 7 mg/dl. Conclusions: A high serum uric acid is an independent predictor of bad prognosis in patients with stable chronic heart failure (Rev M¨¦d Chile 2004; 132: 1031-6
%K Heart failure
%K congestive
%K Hyperuricemia
%K Stroke volume
%K Ventricular ejection fraction
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000900002