%0 Journal Article
%T Growth factor-enriched autologous plasma improves wound healing after surgical debridement in odontogenic necrotizing fasciitis: a case report
%A Rubi Lopez-Fernandez
%A Jorge Ramirez-Melgoza
%A Nora Martinez-Aguilar
%A Alicia Leon-Chavez
%A Daniel Martinez-Fong
%A Juan Gonzalez-Barrios
%J Journal of Medical Case Reports
%D 2011
%I BioMed Central
%R 10.1186/1752-1947-5-98
%X A 69-year old Mexican male had a pain in the maxillar right-canine region and a swelling of the submental and submandibular regions. Our examination revealed local pain, tachycardia, hyperthermia (39ˇăC), and the swelling of bilateral submental and submandibular regions, which also were erythematous, hyperthermic, crepitant, and with a positive Godet sign. Mobility and third-degree caries were seen in the right mandibular canine. Bacteriological cultures isolated streptococcus pyogenes and staphylococcus aureus. The histopathological diagnosis was odontogenic necrotizing fasciitis of the submental and submandibular regions. The initial treatment was surgical debridement and the administration of antibiotics. After cultures were negative, the surgical wound was treated with a growth factor-enriched autologous plasma eight times every third day until complete healing occurred.The treatment with a growth factor-enriched autologous plasma caused a rapid healing of an extensive surgical wound in a patient with odontogenic necrotizing fasciitis. The benefits were rapid tissue regeneration, an aesthetic and a functional scar, and the avoidance of further surgery and possible complications.Cervical necrotizing fasciitis (CNF) is an uncommon, rapidly progressive, and potentially lethal infection comprising skin, subcutaneous tissue, superficial fascia, and occasionally the deep fascia. Its rapid progression results in necrosis and severe systemic toxicity. The incidence of CNF is 2.6% out of the infections of head and neck [1]. Clinical manifestations include pain and local erythema. The skin turns dark with purple dots. The pressure on the zone reveals gas accumulated by the excessive metabolism of bacteria. In advanced stages, thrombosis of local blood vessels of the skin and subcutaneous tissue leads to necrosis and later to gangrene. This infectious pathology is common in people who use drugs and/or alcohol, people with diabetes, immunocompromised individuals, and patient
%U http://www.jmedicalcasereports.com/content/5/1/98