%0 Journal Article
%T Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient
%A Al-Qadheeb Nada
%A Althawadi Sahar
%A Alkhalaf Abdulaziz
%A Hosaini Suleiman
%J Annals of Saudi Medicine
%D 2010
%I King Faisal Specialist Hospital and Research Centre
%X Carbapenemase-producing Klebsiella pneumoniae infections carry serious clinical and infection-control implications. Isolates possessing such hydrolyzing enzymes have been described in the United States and around the world. Besides being resistant to carbapenems, they usually confer resistance to fluoroquinolones, piperacillin-tazobactam, and extended-spectrum cephalosporins. Tigecycline demonstrates in vitro activity against these organisms, but reported resistance raises concern about tigecycline use for these infections. We describe a carbapenemase-producing K pneumoniae evolving resistance to tigecycline in a 75-year-old male after a prolonged stay in a critical care unit.
%U http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=5;spage=404;epage=407;aulast=Al-Qadheeb