%0 Journal Article
%T Solitary Peutz-Jeghers type hamartomatous polyps in the duodenum are not always associated with a low risk of cancer: two case reports
%A Yusuke Sekino
%A Masahiko Inamori
%A Mitsuru Hirai
%A Kaori Suzuki
%A Kaoru Tsuzawa
%A Keiko Akimoto
%A Ayako Takahata
%A Nobutaka Fujisawa
%A Kumiko Saito
%A Akisa Tsunemi
%A Michio Tanaka
%A Hiroshi Iida
%A Yasunari Sakamoto
%A Hirokazu Takahashi
%A Tomoko Koide
%A Chikako Tokoro
%A Yasunobu Abe
%A Atsushi Nakajima
%A Shin Maeda
%A Shigeru Koyama
%J Journal of Medical Case Reports
%D 2011
%I BioMed Central
%R 10.1186/1752-1947-5-240
%X In case one, we describe an 84-year-old Japanese man with a 14 mm duodenal polyp. Endoscopic mucosal resection was performed and histological examination showed findings suggestive of a hamartomatous polyp with a focus of well-differentiated adenocarcinoma. In case two, we describe a 76-year-old Japanese man who had been treated for prostate, rectal and lung cancer. Upper gastrointestinal endoscopy revealed a duodenal polyp measuring 15 mm in diameter. Endoscopic mucosal resection was performed, and histological examination showed findings suggestive of a hamartomatous polyp. Liver and thyroid cancers were found after the endoscopic treatment.Although duodenal solitary hamartomatous polyps are associated with a lower risk of cancer, four patients, including our cases, have been diagnosed with cancerous polyps. Patients with duodenal solitary hamartomatous polyps should be treated by endoscopic or surgical resection and need whole-body screening.Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant syndrome which is characterized by gastrointestinal hamartomatous polyps and mucocutaneous pigmentation [1,2], first described by Peutz in 1921 [3].A hamartomatous polyp without associated mucocutaneous pigmentation or a family history of PJS is diagnosed as a solitary Peutz-Jeghers type hamartomatous polyp [4]. As compared with PJS, Peutz-Jeghers type hamartomatous polyps are diagnosed with a lower risk of cancer [5] and have been regarded as a different disorder from PJS.We report two cases with a solitary Peutz-Jeghers type hamartomatous polyp treated by endoscopic mucosal resection.Case 1 is an 84-year-old Japanese man with previous medical history of hypertension, chronic hepatitis C infection, idiopathic thrombocytopenic purpura and colon polyps (tubular adenoma and tubulovillous adenoma). He had no mucocutaneous pigmentation or family history of PJS. An upper gastrointestinal endoscopy revealed a lobular polyp measuring 14 mm in diameter, in the superior duodena
%U http://www.jmedicalcasereports.com/content/5/1/240