%0 Journal Article
%T 18F-fluorodeoxyglucose positron emission tomography-positive sarcoidosis after chemoradiotherapy for Hodgkin¡¯s disease: a case report
%A Martin H Cherk
%A Alan Pham
%A Andrew Haydon
%J Journal of Medical Case Reports
%D 2011
%I BioMed Central
%R 10.1186/1752-1947-5-247
%X We report the case of a 33-year-old Caucasian woman of Mediterranean descent with newly diagnosed 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scan-positive, early-stage Hodgkin's disease involving the cervical nodes who, despite having an excellent clinical response to chemotherapy, had a persistent 18F-FDG PET scan-positive study, which was suggestive of residual or progressive disease. A subsequent biopsy of her post-chemotherapy PET-positive nodes demonstrated sarcoidosis with no evidence of Hodgkin's disease.This case highlights the fact that abnormalities observed on posttherapy PET/CT scans in patients with Hodgkin's disease are not always due to residual or progressive disease. An association between Hodgkin's disease and/or its treatment with an increased incidence of granulomatous disease appears to exist. Certain patterns of 18F-FDG uptake observed on PET/CT scans may suggest other pathologies, such as granulomatous inflammation, and because of the significant differences in prognosis and management, clinicians should maintain a low threshold of confidence for basing their diagnosis on histopathological evaluations when PET/CT results appear to be incongruent with the patient's clinical response.The use of positron emission tomography (PET)/computed tomography (CT) to evaluate lymphoma, including Hodgkin's disease, continues to increase worldwide and is considered the standard of care when available for pretreatment staging and assessment of treatment response.PET has been demonstrated to modify disease stage (usually upstage) in about 15% to 20% of patients and affect therapeutic management in about 5% to 15% of patients [1]. PET is considered significantly more accurate than CT for the assessment of treatment response because of its ability to distinguish between metabolically active tumor or fibrosis in posttherapy residual masses, which are present in approximately two-thirds of patients with Hodgkin's d
%U http://www.jmedicalcasereports.com/content/5/1/247