%0 Journal Article
%T Evidence of a pharmacodynamic EEG profile in rats following clonidine administration using a nonlinear analysis
%A Azulay David-Olivier D
%A Renoux Benjamin
%A Ivarsson Magnus
%J Nonlinear Biomedical Physics
%D 2011
%I 
%R 10.1186/1753-4631-5-4
%X Background Changes caused by clonidine in rodent electroencephalograms (EEG) have been reported with some inconsistency. For this reason, a pre-clinical study was conducted in order to confirm previous findings with both a standard spectral analysis and a sleep stage scoring procedure. In addition, a nonlinear technique for analysing the time-varying signals was implemented to compare its performance against conventional approaches. Results The nonlinear method succeeds in quantifying all dose-related responses from the data set relying solely on the EEG trace. Conclusions Nonlinear approaches can deliver a suitable alternative to the sleep-stage scoring methods commonly used for drug effect detection.
%U http://www.nonlinearbiomedphys.com/content/5/1/4