%0 Journal Article
%T Relaci¨®n de la genotipificaci¨®n de Helicobacter pylori con la forma e intensidad de la gastritis en poblaci¨®n adulta portadora de patolog¨ªa g¨¢strica benigna Association between helicobacter pylori genotype and the severity of gastritis in infected adults
%A Juan Carlos Araya O
%A Leonardo Anabal¨®n R
%A Iv¨¢n Roa E
%A Mar¨ªa Bravo E
%J Revista m¨¦dica de Chile
%D 2004
%I Sociedad M¨¦dica de Santiago
%X Background: The damaging capacity of Helicobacter pylori is variable and depends, in part, on its genetic polymorphism. Aim: To study H pylori genes vacA, cagA and iceA and the relationship of these genotypes with the features of acute damage in chronic gastritis. Material and methods: Gastric endoscopic biopsies were obtained in 75 adults for pathological study and genetic typification of H pylori by specific PCR. Results: In only 64 cases, complete information was available. In 53 of these, there was H pylori infection demonstrated by PCR. Twenty one percent had infection by two or more H pylori strains, vacA gene had genotypes s2/m2, s1/m1 and s1/m2 in 36, 25 and 8% of cases respectively, cagA gene was present in 49% of infected patients. iceA gene had genotypes iceA 1 ad iceA 2 in 15 and 60% of patients respectively. The presence of cagA or alleles s1/m1 and s1/m2 of vacA gene was directly correlated with polymorphonuclear infiltration and the severity of epithelial damage. The genotype s2/m2 of vacA gene was significantly associated with a milder or absent mucosal damage. No association was found between iceA alleles and the pathological features of gastritis. Conclusions: Alleles of vacA and cagA genes of H pilory are associated with the severity of gastric mucosal damage
%K Gastritis
%K Genes
%K bacterial
%K Helicobacter pylori
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001100002