%0 Journal Article
%T Sleep in Wilson¡äs disease: Questionnaire based study
%A Netto Archana
%A Sinha Sanjib
%A Taly Arun
%A Panda Samhita
%J Annals of Indian Academy of Neurology
%D 2011
%I Medknow Publications
%X Objective: We proposed to detect sleep abnormalities in Wilson¡äs disease, (WD) using sleep questionnaires. Materials and Methods: Twenty-five patients (M:F = 18:7; age: 24.4 ¡À 9.2 years) with WD and 24 controls (all males; age: 33.1 ¡À 9.7 years) were recruited. They underwent phenotypic/magnetic resonance imaging (MRI) evaluation followed by administration of Pittsburg Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) questionnaires. Results: The mean age at presentation and diagnosis was 24.4 ¡À 9.2 and 17.6 ¡À 7.5 years, respectively. The duration of illness at diagnosis was 14 ¡À 21.9 months. On PSQI, 15 patients with WD had abnormal PSQI scores of >5 as compared to 6 patients among the controls. The mean PSQI score was significantly more (P = 0.03) in patients compared to the controls. The PSQI worst scores were noted only in WD. Evaluation with ESS showed that three patients with WD scored >10/24, while two among the controls qualified for excessive daytime sleepiness. Overall, assessment by sleep questionnaires detected abnormality in 16 patients with WD as compared to 8 controls (P = 0.004). Subgroup analysis revealed that patients whose duration of illness was >8 years and who were on decoppering treatment had significantly lesser excessive daytime somnolence. Conclusions: Sleep disturbances were observed more often in WD than in controls. Better designed studies will provide a better understanding.
%K Epworth sleepiness scale
%K Pittsburg sleep quality index
%K sleep
%K sleep questionnaire
%K Wilson¡äs disease
%U http://www.annalsofian.org/article.asp?issn=0972-2327;year=2011;volume=14;issue=1;spage=31;epage=34;aulast=Netto