%0 Journal Article
%T Cellular basis of Alzheimer¡äs disease
%A Bali Jitin
%A Halima Saoussen
%A Felmy Boas
%A Goodger Zoe
%J Annals of Indian Academy of Neurology
%D 2010
%I Medknow Publications
%X Alzheimer¡äs disease (AD) is the most common form of neurodegenerative disease. A characteristic feature of the disease is the presence of amyloid-¦Â (A¦Â) which either in its soluble oligomeric form or in the plaque-associated form is causally linked to neurodegeneration. A¦Â peptide is liberated from the membrane-spanning -amyloid precursor protein by sequential proteolytic processing employing ¦Â- and ¦Ã-secretases. All these proteins involved in the production of A¦Â peptide are membrane associated and hence, membrane trafficking and cellular compartmentalization play important roles. In this review, we summarize the key cellular events that lead to the progression of AD.
%K Alzheimer¡äs disease
%K amyloid precursor protein
%K ¦Â-secretase
%K secretase
%K amyloid
%K trafficking
%K endocytosis
%K exosomes
%U http://www.annalsofian.org/article.asp?issn=0972-2327;year=2010;volume=13;issue=6;spage=89;epage=93;aulast=Bali