%0 Journal Article
%T The Effect of Hydro-Alcoholic Extract of Grape Seed (Vitis vinifera) on Sugar and Lipids in Serum of Diabetic Rats
%A Zohre Ganjali
%A Fereshteh Javadian
%A Jasem Estakhr
%A Abbas Heidari
%J International Journal of Animal and Veterinary Advances
%D 2012
%I Maxwell Science Publication
%X Nowadays, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. This study aimed at assessing the effect of Grape Seed extract on the blood glucose and lipid profile in diabetic rats. Thirty male adult rats were randomly selected and divided into three groups as nondiabetic control; diabetic control; diabetic rats treated with hydroalcoholic extract of grape seed. In diabetic groups, alloxan monohydrate (120 mg/kg) was injected intraperitoneally to develop diabetes. Then the Test group received intraperitoneal injection of hydro-alcoholic extract of grape seed (100 mg/kg). At last, glucose, cholesterol, triglyceride, HDL, VLDL, LDL and insulin contents of the rats' serum sample were determined. Diabetic rats treated with extract showed a significant decrease in blood glucose level (p<0.05). Furthermore, compared diabetic group, in the extract-treated rats, there was a significant decrease in serum contents of total cholesterol (TC) ,LDL,VLDL and TG, but a significant increase in insulin level and HDL (p<0.05). These results show that the hydroalcoholic extract of Grape Seed may be effective in the treatment of diabetes. This effect can be due to the presence of flavonoides and their antioxidant features.
%K Blood sugar
%K grape seed
%K insulin
%K lipid profile
%U http://www.maxwellsci.com/jp/abstract.php?jid=IJAVA&no=208&abs=04