%0 Journal Article
%T Preparation and In-Vitro Evaluation of Sustained-Release Matrix Tablets of Diltiazem
%A P. Khemariya
%A A.K. Jain
%A M. Bhargava
%A S.K. Singhai
%J International Journal of Advances in Pharmaceutical Sciences
%D 2011
%I 
%R 10.5138/176
%X The purpose of the present research work was develop once-daily sustained-release matrix tablet containing water-soluble drug (Diltiazem) that is a novel calcium channel blocker used in cardiovascular diseases, by utilizing a combination of Hypromellose (HPMC), Eudragit with different grades and finally milled Ethyl cellulose. Tablets were prepared by the wet granulation method. The prepared granules and tablets were evaluated based on a range of parameters and in vitro drug release profile. Lastly, tablets shown approx 92%, 97% and 99 % drug release at the last dosing interval. Keywords:- Sustain release; Diltiazem;HPMC
%K ustain release
%K Diltiazem
%K HPMC
%U http://www.arjournals.org/index.php/ijaps/article/view/176