%0 Journal Article
%T Immune reconstitution inflammatory syndrome associated with acquired immunodeficiency syndrome-related gastrointestinal limited Kaposi's sarcoma presenting as acute intestinal obstruction: a case report
%A Jyotirmoy Pal
%A Ankit Shrivastav
%A Hari Pathak
%A Dipendra Sarkar
%J Journal of Medical Case Reports
%D 2011
%I BioMed Central
%R 10.1186/1752-1947-5-327
%X A 36-year-old Asian Indian male, newly diagnosed with AIDS and treatment na£żve, was started on highly active antiretroviral therapy (HAART). He developed acute intestinal obstruction after four weeks of therapy. A laparotomy was done with excision and adhesiolysis leading to relief of symptoms. A histology report revealed the lesion to be Kaposi's sarcoma. Our patient was diagnosed to be having immune reconstitution inflammatory syndrome associated with AIDS-associated gastrointestinal limited Kaposi's sarcoma, which presented as acute intestinal obstruction. Our patient was treated with paclitaxel post-operatively and HAART was continued. Our patient responded to therapy.Immune reconstitution inflammatory syndrome involving Kaposi's sarcoma may occur in HAART-na£żve individuals with AIDS-related Kaposi's sarcoma. Gastrointestinal Kaposi's sarcoma may present with sudden increase in size or inflammation leading to acute intestinal obstruction. This does not indicate failure of HAART or a need for changes in anti-retroviral regimen.Kaposi's sarcoma (KS) remains the most common tumor in individuals infected with human immunodeficiency virus (HIV) and is associated with significant morbidity and mortality. Highly active anti-retroviral therapy (HAART) for acquired immunodeficiency syndrome (AIDS) decreases the incidence of KS, prolongs the time to treatment failure in KS, leads to resolution of individual lesions, and also decreases KS herpes virus viral load. Immune reconstitution inflammatory syndrome (IRIS) is well recognized as a complication of using HAART for treating AIDS, especially when associated with mycobacterial, fungal or viral infection. Our case demonstrates that KS can worsen during HAART-associated increases in the cluster of differentiation 4 (CD4) count and KS is an IRIS-associated disease. IRIS-KS may be associated with significant complications. It is important for clinicians to realize that KS-associated IRIS does not indicate failure of HAART or
%U http://www.jmedicalcasereports.com/content/5/1/327