%0 Journal Article
%T Juvenile polyposis syndrome affecting the stomach: A case report
%A Steven Kelly
%A Simon Dwerryhouse
%A Peter Safranek
%A Richard Hardwick
%J Journal of Medical Case Reports
%D 2008
%I BioMed Central
%R 10.1186/1752-1947-2-314
%X A 51-year-old man presented with symptoms of gastric outlet obstruction and upper gastrointestinal bleeding. Gastroscopy showed massive gastric polyposis with a large antral polyp that had prolapsed through the pylorus causing gastric outlet obstruction. Initially endoscopic polypectomy was performed, but due to progressive symptoms a total gastrectomy was then performed. Histology confirmed massive gastric juvenile polyposis.Massive gastric polyposis is an uncommon manifestation of juvenile polyposis syndrome. This case illustrates important principles in managing this condition.Juvenile polyposis syndrome (JPS) is a rare autosomal dominant inherited condition. These juvenile polyps can occur anywhere in the gastrointestinal tract but usually predominate in the colon. We report an unusual case of massive gastric polyposis occurring in a patient with juvenile polyposis syndrome. Due to the severity of the disease he required total gastrectomy.A 51-year-old man with known juvenile polyposis syndrome had been in a gastrointestinal polyposis screening program which had starting twenty years earlier when he was initially diagnosed with gastric and colonic juvenile polyps. Two years ago he required a laparotomy and small bowel resection for a large intussuscepting jejunal juvenile polyp causing obstruction.Clinically there were no extraintestinal manifestations of hamartomatous polyposis syndromes. There was a strong family history of gastrointestinal malignancy. The patient had two brothers both of whom were diagnosed with colon cancer in their fifties. The patient had two children in their twenties, both of whom had colonic juvenile polyps and one had had surgery for colonic cancer.The patient presented with symptoms of vomiting, early satiety, weight loss and upper gastrointestinal bleeding. Serum haemoglobin measurement was 5 g/dl. Gastroscopy and barium meal examination revealed massive gastric polyposis with a prominent gastric antral polyp prolapsing through the p
%U http://www.jmedicalcasereports.com/content/2/1/314