%0 Journal Article
%T Compartive Modeling of Human Siglec-8 Membrane Protein
%A Shagunbansali Shagunbansali
%A Sreenivas Enaganti
%A Saritha Devaraju
%A Harikrishna N
%J International Journal of Advances in Pharmaceutical Sciences
%D 2011
%I 
%R 10.5138/199
%X Many cells are present in our body and play different role. But some cells only involved in the inflammatory process.Siglec-8 is a member of the CD33 Sialicacid binding Ig-like lectins membrane proteins that constitute a distinct subset of the Ig super- family and are characterized by their sequence similarities and abilities to bind sialic acids in glycoproteins and glycolipids . Siglec-8 found predominantly on human eosinophils. Siglec is also present in the airway passages.so they involved in the asthma. Thus, it is a potential chemotherapeutic target for asthma treatment. Structure of this enzyme in Homosapiens has not yet been elucidated. We used the structural template of N-Terminal Domains of Native Siglec-5 from Homosapiens for modeling of siglec-8 structure by using Modeller.Thus we analyses and propose the usefulness of the modeled siglec-8 for the design of suitable agonist towards the treatment of asthma. Keywords: Asthma; Siglec-8; Homo sapiens; Modeler; Homology Modeling;
%K Asthma
%K Siglec-8
%K Homo sapiens
%K Modeler
%K Homology Modeling
%U http://www.arjournals.org/index.php/ijaps/article/view/199