%0 Journal Article
%T Allogeneic hematopoietic stem cell transplantation in China: where we are and where to go
%A Meng Lv
%A Xiao-Jun Huang
%J Journal of Hematology & Oncology
%D 2012
%I BioMed Central
%R 10.1186/1756-8722-5-10
%X It has been more than thirty years since the first allogeneic bone marrow transplantation was successfully performed in China [1], and during the past decades, substantial progress has been made in the field of allogeneic hematopoietic stem cell transplantation (allo-HSCT).Currently, there are 104 transplant units certified by China's Ministry of Health and the China Marrow Donor Program. Of these centers, 60% are active and routinely perform HSCT. According to data collected from 50 active centers by the Chinese Hematopoietic Stem Cell Transplantation Registry Group (2007-2011), 5 centers performed more than 100 HSCT cases annually, and approximately 30 centers performed 20-100 cases per year. The total number of HSCT cases in all 50 active centers increased steadily from 1093 cases in 2007 to 1633 cases in 2010 [2]. By the end of 2011, this figure has been greater than 2000 by the preliminary statistics.The types of donor sources for Allo-HSCT in China are related identical (47.3%), related mismatched/haploidentical (30.8%), unrelated matched (12.1%), unrelated mismatched (7.7%), umbilical cord blood (UCB, 2.2%) and Allo-HSCT accounts for 91% of the total HSCT cases. (Figure 1) [2]. These data are quite different from those reported by the CIBMTR(Center for International Blood and Marrow Transplant Research), which show that autologous HSCT takes up 58% of the total HSCT cases and that unrelated donors comprise nearly half of all the allogeneic HSCT graft sources in the USA. Data on haploidentical HSCT(Haplo-HSCT) cases are not available [3]. The distribution of diseases occurring in allogeneic transplant recipients is as follows: acute myeloid leukemia (AML) (34%), acute lymphoblastic leukemia (ALL) (24%), chronic myeloid leukemia (CML) (20%), myelodysplastic syndrome (MDS) (7%), aplastic anemia (AA) (7%), Mediterranean anemia (MIA) (2%), non-Hodgkin's lymphoma (NHL) (3%), and other diseases (2%) (Figure 2). The proportions of disease types receiving allo-HSCT ar
%K China
%K Allo-HSCT
%K Haploidentical
%K Relapse
%K GVHD
%K Elderly patients
%U http://www.jhoonline.org/content/5/1/10