%0 Journal Article
%T MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status
%A Isabella Faraoni
%A Serena Laterza
%A Davide Ardiri
%A Claudia Ciardi
%A Francesco Fazi
%A Francesco Lo-Coco
%J Journal of Hematology & Oncology
%D 2012
%I BioMed Central
%R 10.1186/1756-8722-5-26
%X We found that miR-424 was down-modulated in AMLs with NPM1mutA regardless of FLT3 status. On the contrary, miR-155 showed up-regulation in patients with FLT3 internal tandem duplications (ITD) with or without NPM1 mutations. No significant associations were found by analyzing miR-223 and miR-17-5p in relation to FLT3 and NPM1 status.This study supports the view that major genetic subsets of CN-AML are associated with distinct miRNA signatures and suggests that miR-424 and miR-155 deregulation is involved in the pathogenesis of CN-AML with NPM1 and FLT3-ITD mutations, respectively.
%K Cytogenetically normal AML
%K MiR-424
%K MiR-155
%K NPM1
%K FLT3-ITD
%U http://www.jhoonline.org/content/5/1/26/abstract