%0 Journal Article
%T 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors
%A Kevin E Yarasheski
%A Erin Laciny
%A E Turner Overton
%A Dominic N Reeds
%A Michael Harrod
%A Steven Baldwin
%A Victor G Davila-Roman
%J Journal of Inflammation
%D 2012
%I BioMed Central
%R 10.1186/1476-9255-9-26
%X We studied 9 HIV-infected participants with fully suppressed HIV viremia on antiretroviral therapy (8 men, median age 52£¿yrs, median BMI 29£¿kg/m2, median CD4 count 655 cells/¦ÌL, 33% current smokers) and 5 HIV-negative participants (4 men, median age 44£¿yrs, median BMI 25£¿kg/m2, no current smokers). Mean Framingham Risk Scores were higher for HIV-infected persons (9% vs. 2%, p£¿<£¿0.01). 18FDG (370£¿MBq) was administered intravenously. 3D-PET-CT images were obtained 3.5£¿hrs later. 18FDG uptake into both carotid arteries and the aorta was compared between the two groups.Right and left carotid 18FDG uptake was greater (P£¿<£¿0.03) in the HIV group (1.77 ¡À0.26, 1.33 ¡À0.09 target to background ratio (TBR)) than the control group (1.05£¿¡À£¿0.10, 1.03£¿¡À£¿0.05 TBR). 18FDG uptake in the aorta was greater in HIV (1.50 ¡À0.16 TBR) vs control group (1.24£¿¡À£¿0.05 TBR), but did not reach statistical significance (P£¿=£¿0.18).Carotid artery 18FDG PET-CT imaging detected differences in vascular inflammation and early atherosclerosis between HIV-infected adults with CVD risk factors and healthy HIV-seronegative controls. These findings confirm the utility of this molecular level imaging approach for detecting and quantifying glucose uptake into inflammatory macrophages present in metabolically active, rupture-prone atherosclerotic plaques in HIV infected adults; a population with increased CVD risk.
%K Pathophysiologic molecular-level biomarker
%K Atherogenesis
%K Non-invasive imaging
%K Infectious disease
%U http://www.journal-inflammation.com/content/9/1/26/abstract