%0 Journal Article
%T St  enie BDNF w surowicy a nasilenie objaw¨®w depresji
%A Jakub Filu£¿
%A Janusz Rybakowski
%J Neuropsychiatria i Neuropsychologia
%D 2010
%I Termedia Publishing House
%X Aim of the study was studying of connection betweenserum BDNF ¨C brain derived neurotrophic factor level ¨Cin severely depressed patients, and severity of symptomsin depression.Material and methods: In studies took part 45 womenhospitalized with the diagnosis of depressive episode incourse of unipolar or bipolar disorder. Severity of depressionwas assessed with Hamilton Rating Scale forDepression (HAM-D). Serum BDNF was assayed withsandwich ELISA method using Quantikine HumanBDNF Immunoassay (R&D Systems).Results:We found statistically significant negative correlationbetween serum BDNF levels in severe depressionand severity of depression (measured with HAM-D).Statistical significance concerns the general assessment,symptoms of cluster II (depression related anxiety andinsomnia) and such symptoms as anxiety psychic,insight.Conclusions: Our results suggest correlation betweenBDNF serum level and severity of psychopathologicalsigns in depression.
%K brain-derived neurotrophic factor
%K BDNF
%K depression
%K Hamilton Depression Scale
%U http://www.termedia.pl/Artykul-oryginalny-Stezenie-BDNF-w-surowicy-a-nasilenie-objawow-depresji,46,16252,1,0.html