%0 Journal Article
%T Study of Excipients Affecting Dissolution Profile of Drug with Special Emphasis on Co Processed Excipients
%A Parmar K
%A Vyas J
%A Patel N
%A Patel R
%J International Journal For Pharmaceutical Research Scholars
%D 2013
%I International Journals for Pharmaceutical Research Scholars
%X The main aim of present work is to study the impact of various excipients and co-processed excipientson dissolution rate. Direct compression is the preferred method for the preparation of tablets. Coprocessing is the one of the most widely explored and commercially utilized method for the preparationof directly compressible vehicle. The objective of present study is to prepare and characterize various coprocessed excipients and its application in tablet formulation. Co-processed excipient prepared wascharacterized by flow properties, solubility, Hardness, Friability, % drug content in tablet formulation.FTIR and SEM show no physical interaction between them with no chemical change. Co processing ofexcipients was evaluated for Drug release, mean dissolution time and dissolution efficiency Sucrose:MCC (2:1) used to extend the drug release up to 6 hr, we can prepare sustain release tablet of this COprocessing by incorporation of sustain release polymer. MCC: Kyron was used to prepare immediatedrug release. So based on these properties we was prepared immediate release formulation and sustainrelease formulation. Co-processing of Sucrose: MCC have been used to achieve sustain release byincorporation of pectin, by using this combination we can achieve sustain release up to 10 hr similarlyKyron: MCC was used in immediate release formulation. Comparison with both IR and SR marketedproduct and evaluated for F2 test shows there is similarity in dissolution profile between both thebatches.
%K Aceclofenac
%K Co processing
%K MCC: Kyron
%K Sucrose: MCC
%K Excipients
%U http://www.ijprs.com/download.php?file=1372573583.pdf