%0 Journal Article
%T An Introduction to a Hyphenated Technique: HPLC-SPE-NMR
%A Patel RC
%A Dixit PB
%A Vyas HA
%A Patel NK
%J International Journal For Pharmaceutical Research Scholars
%D 2013
%I International Journals for Pharmaceutical Research Scholars
%X Liquid chromatography¨Csolid phase extraction¨Cnuclear magnetic resonance (HPLC-SPE-NMR), noveland highly promising hyphenated technique which is based on post-column analyte trapping by solidphaseextraction. The analytes are subsequently eluted from the SPE cartridges using deuteratedsolvents. This indirect HPLC-NMR hyphenation offers numerous advantages compared to direct HPLCNMRmethods. Multiple trapping leads to a dramatic increase of analyte amounts available for NMR,enabling acquisition of high-quality 2D NMR data within a short time. The well-defined NMR solventconditions make spectra comparisons feasible, which means databases and spectra catalogues.
%K HPLC
%K Solid Phase Extraction (SPE)
%K NMR
%U http://www.ijprs.com/download.php?file=1367417588.pdf