%0 Journal Article
%T An Overview on Osmotic Controlled Drug Delivery System
%A Thummar A
%A Kalyanwat R
%A Tiwari A
%A Shrivastav B
%J International Journal For Pharmaceutical Research Scholars
%D 2013
%I International Journals for Pharmaceutical Research Scholars
%X This paper reviews constructed drug delivery systems applying osmotic principles for controlled drugrelease from the formulation. Osmotic devices which are tablets coated with walls of controlled porosityare the most promising strategy based systems for controlled drug delivery. In contrast to commontablets, these pumps provide constant (zero order) drug release rate. When these systems are exposed towater, low levels of water soluble additive is leached from polymeric material i.e. semipermeablemembrane and drug releases in a controlled manner over an extended period of time. The main clinicalbenefits of oral osmotic drug delivery system are their ability to improve treatment tolerability andpatient compliance. These advantages are mainly driven by the capacity to deliver drugs in a sustainedmanner, independent of the drug chemical properties, of the patient¡¯s physiological factors or followingfood intake. This review brings out the theoretical concept of drug delivery, history, advantages anddisadvantages of the delivery systems, types of oral osmotic drug delivery systems, factors affecting thedrug delivery system and marketed products.
%K Osmosis
%K osmotic pressure
%K Osmotic pump
%K Zero-order release
%K Oral osmotic systems
%U http://www.ijprs.com/download.php?file=1372577029.pdf