%0 Journal Article
%T Comparison of S100¦Â levels, and their correlation with hemodynamic indices in patients undergoing coronary artery bypass grafting with three different anesthetic techniques
%A Singh Sarvesh
%A Kapoor Poonam
%A Chowdhury Ujjwal
%A Kiran Usha
%J Annals of Cardiac Anaesthesia
%D 2011
%I Medknow Publications
%X Cardiac surgery with aid of cardiopulmonary bypass (CPB) is associated with neurological dysfunction. The presence of cerebrospecific protein S100¦Â in serum is an indicator of cerebral damage. This study was designed to evaluate the influence of three different anesthesia techniques, on S100¦Â levels, in patients undergoing coronary artery bypass grafting on CPB. A total of 180 patients were divided into three groups - each of who received sevoflurane, isoflurane and total intravenous anesthesia as part of the anesthetic technique, respectively. S100 were evaluated from venous sample at following time intervals - prior to induction of anesthesia (T1), after coming off CPB (T2); 12 h after aortic cross clamping (T3) and 24 h after aortic cross clamping (T4). In all three groups, maximal rise in S100¦Â levels occurred after CPB which gradually declined over next 24 h, the levels at 24 h post-AOXC being significantly higher than baseline levels. Significantly low levels of S100¦Â were noted at all postdose hours in the sevoflurane group, as compared to the total intravenous anesthesia (TIVA) group, and at 12 and 24 h postaortic cross clamp, in comparison to the isoflurane group. Comparing the isoflurane group with the TIVA group, the S100 levels were lower in the isoflurane group only at 24 h postaortic cross clamp. It was concluded that maximum rise in S100¦Â levels occurs immediately after CPB with a gradual decline in next 24 h. The rise in S100¦Â levels is significantly less in patients administered sevoflurane in comparison to isoflurane or TIVA. Hemodynamic parameters had no influence on the S100¦Â levels during the first 24 h after surgery.
%K S100¦Â levels
%K isoflurane
%K sevoflurane
%K total intravenous anesthesia
%U http://www.annals.in/article.asp?issn=0971-9784;year=2011;volume=14;issue=3;spage=197;epage=202;aulast=Singh