%0 Journal Article
%T Synthesis, Characterization and Biological Screening of novel N-[2-chloro-4-(trifluromethyl) phenyl]-4-(substituted phenyl)-3, 6-Dimethyl-2-oxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxamide
%A Nitesh Chauhan
%A Kiran Nimavat
%A Kartik Vyas
%J International Journal For Pharmaceutical Research Scholars
%D 2012
%I International Journals for Pharmaceutical Research Scholars
%X N-[2-chloro-4-(trifluromethyl)phenyl]-4-(substitutedphenyl)-3,6-Dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (4a-o) are synthesized. The synthesis of (4a-o) was achieved by acid catalysed cyclocondensation of N-(2-chloro-4-(trifluromethyl) phenyl)-3-oxobutanamide, N-methyl urea and benzaldehydes. The products were characterized by FT-IR, mass spectra, 1H NMR and elemental analyses. The newly synthesized compounds were subjected to various biological activities viz., antimicrobial.
%K Pyrimidine
%K N-(2-chloro-4-(trifluromethyl) phenyl)-3-oxobutanamide
%K N-methyl urea
%K Multi component cyclocondensation
%U http://www.ijprs.com/download.php?file=1342540935.pdf