%0 Journal Article
%T Digital Operation of Microelectronic Circuits Analogous to Protein Hydrogen Bonding Networks
%A Elitsa Gieva
%A Rostislav Rusev
%A George Angelov
%A Marin Hristov
%J International Journal Bioautomation
%D 2012
%I Academic Publishing House
%X Two hydrogen bonding networks with water molecules and branching residues extracted from ¦Â-lactamase protein are investigated and their proton transfer characteristics are studied by creating analogous electrical circuits consisting of block-elements. The block-elements and their proton transfer are described by polynomials that are coded in Matlab and in Verilog-A for use in the Spectre simulator of Cadence IC design system. DC and digital pulse analyses are performed to demonstrate that some circuit outputs behave as repeaters while other - behave as inverters. The results also showed that the HBN circuits might behave as a D-latch and a demultiplexer.
%K Hydrogen Bonding Networks (HBNs)
%K Proteins
%K ¦Â-lactamase
%K Behavioral modeling
%K Verilog-A
%U http://www.clbme.bas.bg/bioautomation/2012/vol_16.4/files/16.4_06.pdf