%0 Journal Article
%T Making SharePoint£¿ Chemically Aware£¿
%A Kartik Tallapragada
%A Joseph Chewning
%A David Kombo
%A Beverly Ludwick
%J Journal of Cheminformatics
%D 2012
%I BioMed Central
%R 10.1186/1758-2946-4-1
%X This paper describes the implementation of a Chemically Aware£¿ system to supplement SharePoint. A Chemically Aware SharePoint (CASP) allows users to tag documents by drawing a structure and associating it with the related content. It also allows the user to search SharePoint software content and internal/external databases by carrying out substructure, similarity, SMILES, and IUPAC name searches. Building on traditional search, CASP takes SharePoint one step further by providing a intuitive GUI to the researchers to base their search on their knowledge of chemistry than textual search. CASP also provides a way to integrate with other systems, for example a researcher can perform a sub-structure search on pdf documents with embedded molecular entities.A Chemically Aware£¿ system supplementing SharePoint is a step towards making drug discovery process more efficient and also helps researchers to search for information in a more intuitive way. It also helps the researchers to find information which was once difficult to find by allowing one to tag documents with molecular entities and integrating with image recognition software to find information from pdf documents.The amount of data generated during the transition of a single compound from preclinical stages to commercialization can easily range in Terabytes. So just imagine having a million compounds and the amount of data accumulated against them would be overwhelming. According to a survey [1], over 42 million biological test results were deposited in the PubChem database with 761,772 unique chemical structures. In the above scenario a traditional text search would fail to aggregate all the data; for example if one searched for varenicline, a compound launched by Pfizer as an aid to smoking cessation treatment [2], it would exclude the content pertaining to Chantix/Champix (trade names in the USA and Canada, respectively) and varenicline's IUPAC name (7,8,9,10-tetrahydro- 6,10-methano- 6H-pyrazino (2,3-h)(3) benzaz
%U http://www.jcheminf.com/content/4/1/1