%0 Journal Article
%T The emerging neurobiology of cholesterol
%A Mike A Simmonds
%J Neurobiology of Lipids
%D 2002
%I 
%X Although cholesterol gets a bad press as a cause of vascular disease, it is, of course, an essential component of all mammalian cells. In neurobiology, three quite different roles of cholesterol can be discerned: as a structural component of the plasma membranes of neurones and glia; as the precursor for a cascade of steroidal hormones and mediators affecting both genomic and non-genomic processes in neurones; and as a direct modulator of the functions of certain plasma membrane proteins.
%K Alzheimer
%K Alzheimer's disease
%K amyloid beta precursor
%K cytoskeleton
%K Down syndrome
%K etiology
%K lipids
%K learning
%K memory
%K lipoprotein
%K receptor
%K LTP
%K neurodegeneration marker
%K oxidative stress
%K PHF NFT tau phosphorylation
%K phospholipids
%K secretase
%K synaptic plasticity
%K SREBP
%K therapy
%U http://neurobiologyoflipids.org/content/1/1/