%0 Journal Article
%T The practical implications of using estimated GFR as the presumed reference variable to estimate transplant chronic kidney disease
%A Hamdi Elmoselhi
%A Mohammad Akhtar Hossain
%A Said Khamis
%A Rahul Mainra
%J Nephrology Reviews
%D 2011
%I 
%R 10.4081/nr.2011.e2
%X We determined the proportions of matched kidney transplant isotope GFRs (iGFRs) to the estimated functions (eGFRs) calculated from Isotope Dilution Mass Spectrometry (IDMS), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Cockcroft-Gault (CG) equations. Method: 1403 iGFR/eGFR pairs on 390 kidney transplant patients were compared considering the iGFR or eGFR as the reference or test variable. Results: Conformity of iGFR to CG estimates demonstrated the least bias of 1.3¡À18.4 mL/ min/1.73 m2 (compared to 1.5¡À19.4 and -2.2¡À19.2 for IDMS and CKDI-EPI, P<.05) and CKD-EPI estimates the highest precision of 4.1¡À41.8 (compared to 11.3¡À43.9 for IDMS and 5.7¡À37.3 for CG; P<.05). IDMS eGFR cut-off <60 and <30 mL/min/1.73m2 were correctly matched by iGFR in 79.4% and 49.1% of the times, while CKD-EPI was matched by iGFR in 83.5% and 52.5%. CG was matched in 78.3% and 53.6%. IGFR cut-off levels of <60, and <30 mL/min/1.73m2 were predicted by IDMS in 83.8 % and 64.0% of the times. CKD-EPI was correct in 77.8% and 59.0% and CG in 82.5% and 41.6% respectively. Conclusion: Transplant eGFR results obtained by CKD-EPI or CG are likely to be more precise and less biased than IDMS.
%U http://www.pagepress.org/journals/index.php/nr/article/view/2108