%0 Journal Article
%T Surgically cured hypoglycemia secondary to pleural solitary fibrous tumour: case report and update review on the Doege-Potter syndrome
%A Ahmed Y Kalebi
%A Martin J Hale
%A Michelle L Wong
%A Tessa Hoffman
%A Jill Murray
%J Journal of Cardiothoracic Surgery
%D 2009
%I BioMed Central
%R 10.1186/1749-8090-4-45
%X The occurrence of hypoglycemia with an intrathoracic tumour was first reported by Doege and Potter independently in 1930 hence the eponym Doege-Potter syndrome [DPS] [1,2]. Hyperthrophic osteoarthropathy clinically observed as finger-clubbing is also associated with intrathoracic tumours and goes with the eponym of Pierre-Marie-Bamberg syndrome [PMBS]. In this report we present a previously unpublished but very typical example of the rare occurrence of hypoglycaemia and finger-clubbing with pleural solitary fibrous tumour [SFT] in an adult African male. A detailed updated literature review is presented detailing the histopathology of SFT, pathophysiology of the hypoglycemia and finger clubbing, treatment and outcome of pleural SFT.A 57-year-old male was referred to the Chris Hani Baragwanath Hospital with recurrent episodes of symptoms of severe hypoglycemia including syncope. He had a 20 pack-year history of smoking. He was found on examination to have marked finger-clubbing and decreased breath sounds in the right lower chest, but no other significant clinical findings. Sputum cytology was negative for malignant cells. His blood glucose levels recorded over three consecutive days whilst remained low despite receiving continuous intravenous infusion of 10% dextrose (table 1). His serum insulin and C-peptide levels were also depressed (table 2). A chest radiograph and CT-scan showed a lobulated mass in the right chest suggestive of a benign pleural tumour (figure 1A-B).A percutaneous needle biopsy of the mass showed morphological and immunohistochemical features of a benign SFT. The patient underwent thoracotomy with excision of the bulk of the mass. A small remnant attached to the diaphragm could not be removed. The tumour was large, well-circumscribed and encapsulated, with a tan-coloured whorled cut surface (figure 1C-1D). It weighed 1744 g and measured 20 กม 15 กม 10 cm. There were no areas of intratumoral haemorrhage or necrosis.Microscopic examination of the tum
%U http://www.cardiothoracicsurgery.org/content/4/1/45